A Randomized Controlled Trial of Soy Isoflavone Intake on Mammographic Density among Malaysian Women.

ABSTRACT: Soy intake is associated with lower breast cancer risk in observational studies concerning Asian women, however, no randomized controlled trials (RCT) have been conducted among Asian women living in Asia. This three-armed RCT assessed the effects of one-year soy isoflavone (ISF) intervention on mammographic density (MD) change among healthy peri- and postmenopausal Malaysian women. This study was registered at ClinicalTrials.gov (NCT03686098). Participants were randomized into the 100 mg/day ISF Supplement, 50 mg/day ISF Diet, or control arm, and assessed for change in absolute and relative dense area from digital mammograms conducted at enrolment and after 12 months, compared over time across study arms using Kruskal-Wallis tests. Out of 118 women enrolled, 91 women completed the interven

SUBMITTER: Rajaram N 

PROVIDER: S-EPMC9862880 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature