CAT-Site: Predicting Protein Binding Sites Using a Convolutional Neural Network.

ABSTRACT: Identifying binding sites on the protein surface is an important part of computer-assisted drug design processes. Reliable prediction of binding sites not only assists with docking algorithms, but it can also explain the possible side-effects of a potential drug as well as its efficiency. In this work, we propose a novel workflow for predicting possible binding sites of a ligand on a protein surface. We use proteins from the PDBbind and sc-PDB databases, from which we combine available ligand information for similar proteins using all the possible ligands rather than only a special sub-selection to generalize the work of existing research. After performing protein clustering and merging of ligands of similar proteins, we use a three-dimensional convolutional neural network that takes into

SUBMITTER: Petrovski ZH 

PROVIDER: S-EPMC9862895 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature