Visceral Adipose Tissue Bioenergetics Varies According to Individuals' Obesity Class.

ABSTRACT: Obesity is associated with complex adipose tissue energy metabolism remodeling. Whether AT metabolic reprogramming differs according to body mass index (BMI) and across different obesity classes is unknown. This study's purpose was to evaluate and compare bioenergetics and energy substrate preference of visceral adipose tissue (VAT) pertaining to individuals with obesity class 2 and class 3. VAT obtained from patients with obesity (n = 15) class 2 (n = 7; BMI 37.53 ± 0.58 kg/m²) or class 3 (n = 8; BMI 47.79 ± 1.52 kg/m²) was used to assess oxygen consumption rate (OCR) bioenergetics and mitochondrial substrate preferences. VAT of patients with obesity class 3 presented significantly higher non-mitochondrial oxygen consumption (p < 0.05). In VAT of patients w

SUBMITTER: Topete MV 

PROVIDER: S-EPMC9863201 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature