Differential proteomic profile of lumbar and ventricular cerebrospinal fluid.

ABSTRACT:

Background

Pathological cerebral conditions may manifest in altered composition of the cerebrospinal fluid (CSF). Although diagnostic CSF analysis seeks to establish pathological disturbances in the brain proper, CSF is generally sampled from the lumbar compartment for reasons of technical ease and ethical considerations. We here aimed to compare the molecular composition of CSF obtained from the ventricular versus the lumbar CSF compartments to establish a relevance for employing lumbar CSF as a proxy for the CSF bathing the brain tissue.

Methods

CSF was collected from 46 patients with idiopathic normal pressure hydrocephalus (iNPH) patients during their diagnostic workup (lumbar samples) and in connection with their subsequent CSF diversion shunt surgery (ventricular sampl

SUBMITTER: Rostgaard N 

PROVIDER: S-EPMC9863210 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature