Macrophages as a Potential Immunotherapeutic Target in Solid Cancers.

ABSTRACT: The revolution in cancer immunotherapy over the last few decades has resulted in a paradigm shift in the clinical care of cancer. Most of the cancer immunotherapeutic regimens approved so far have relied on modulating the adaptive immune system. In recent years, strategies and approaches targeting the components of innate immunity have become widely recognized for their efficacy in targeting solid cancers. Macrophages are effector cells of the innate immune system, which can play a crucial role in the generation of anti-tumor immunity through their ability to phagocytose cancer cells and present tumor antigens to the cells of adaptive immunity. However, the macrophages that are recruited to the tumor microenvironment predominantly play pro-tumorigenic roles. Several strategies targeting pr

SUBMITTER: Mishra AK 

PROVIDER: S-EPMC9863216 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature