Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity.

ABSTRACT: Chemokines, a subfamily of the cell cytokines, are low molecular weight proteins known to induce chemotaxis in leukocytes in response to inflammatory and pathogenic signals. A plethora of literature demonstrates that chemokines and their receptors regulate tumor progression and metastasis. With these diverse functionalities, chemokines act as a fundamental link between the tumor cells and their microenvironment. Recent studies demonstrate that the biology of chemokines and their receptor in metastasis is complex as numerous chemokines are involved in regulating site-specific tumor growth and metastasis. Successful treatment of disseminated cancer is a significant challenge. The most crucial problem for treating metastatic cancer is developing therapy regimes capable of overcoming heterogen

SUBMITTER: Saxena S 

PROVIDER: S-EPMC9863248 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature