Innovative Strategies to Overcome Antimicrobial Resistance and Tolerance.

ABSTRACT: Antimicrobial resistance and tolerance are natural phenomena that arose due to evolutionary adaptation of microorganisms against various xenobiotic agents. These adaptation mechanisms make the current treatment options challenging as it is increasingly difficult to treat a broad range of infections, associated biofilm formation, intracellular and host adapted microbes, as well as persister cells and microbes in protected niches. Therefore, novel strategies are needed to identify the most promising drug targets to overcome the existing hurdles in the treatment of infectious diseases. Furthermore, discovery of novel drug candidates is also much needed, as few novel antimicrobial drugs have been introduced in the last two decades. In this review, we focus on the strategies that may help in th

SUBMITTER: Choudhary MI 

PROVIDER: S-EPMC9863313 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature