Monoclonal-Based Antivenomics Reveals Conserved Neutralizing Epitopes in Type I PLA₂ Molecules from Coral Snakes.

ABSTRACT: For over a century, polyclonal antibodies have been used to treat snakebite envenoming and are still considered by the WHO as the only scientifically validated treatment for snakebites. Nevertheless, moderate innovations have been introduced to this immunotherapy. New strategies and approaches to understanding how antibodies recognize and neutralize snake toxins represent a challenge for next-generation antivenoms. The neurotoxic activity of Micrurus venom is mainly due to two distinct protein families, three-finger toxins (3FTx) and phospholipases A₂ (PLA₂). Structural conservation among protein family members may represent an opportunity to generate neutralizing monoclonal antibodies (mAbs) against family-conserved epitopes. In this work, we sought to produce

SUBMITTER: Correa-Netto C 

PROVIDER: S-EPMC9863321 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature