Altered Cerebral Blood Flow in the Progression of Chronic Kidney Disease.

ABSTRACT:

Background

In chronic kidney disease (CKD), cognitive impairment is a definite complication. However, the mechanisms of how CKD leads to cognitive impairment are not clearly known.

Methods

Cerebral blood flow (CBF) information was collected from 37 patients with CKD (18 in stage 3; 19 in stage 4) and 31 healthy controls (HCs). For CKD patients, we also obtained laboratory results as well as neuropsychological tests. We conducted brain perfusion imaging studies using arterial spin labeling and calculated the relationship between regional CBF changes and various clinical indicators and neuropsychological tests. We also generated receiver operator characteristic (ROC) curves to explore whether CBF value changes in certain brain regions can be used to identify CKD.

Results

SUBMITTER: Lin W 

PROVIDER: S-EPMC9863421 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature