Bypassing Mendel's First Law: Transmission Ratio Distortion in Mammals.

ABSTRACT: Mendel's law of segregation states that the two alleles at a diploid locus should be transmitted equally to the progeny. A genetic segregation distortion, also referred to as transmission ratio distortion (TRD), is a statistically significant deviation from this rule. TRD has been observed in several mammal species and may be due to different biological mechanisms occurring at diverse time points ranging from gamete formation to lethality at post-natal stages. In this review, we describe examples of TRD and their possible mechanisms in mammals based on current knowledge. We first focus on the differences between TRD in male and female gametogenesis in the house mouse, in which some of the most well studied TRD systems have been characterized. We then describe known TRD in other mammals, wi

SUBMITTER: Friocourt G 

PROVIDER: S-EPMC9863905 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature