Microbacterium Cluster EA Bacteriophages: Phylogenomic Relationships and Host Range Predictions.

ABSTRACT: Bacteriophages are being widely harnessed as an alternative to antibiotics due to the global emergence of drug-resistant pathogens. To guide the usage of these bactericidal agents, characterization of their host specificity is vital-however, host range information remains limited for many bacteriophages. This is particularly the case for bacteriophages infecting the Microbacterium genus, despite their importance in agriculture, biomedicine, and biotechnology. Here, we elucidate the phylogenomic relationships between 125 Microbacterium cluster EA bacteriophages-including members from 11 sub-clusters (EA1 to EA11)-and infer their putative host ranges using insights from codon usage bias patterns as well as predictions from both exploratory and confirmatory computational methods

SUBMITTER: Milhaven M 

PROVIDER: S-EPMC9863963 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature