Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals.

ABSTRACT: Transdermal delivery provides numerous benefits over conventional routes of administration. However, this strategy is generally limited to a few molecules with specific physicochemical properties (low molecular weight, high potency, and moderate lipophilicity) due to the barrier function of the stratum corneum layer. Researchers have developed several physical enhancement techniques to expand the applications of the transdermal field; among these, microneedle technology has recently emerged as a promising platform to deliver therapeutic agents of any size into and across the skin. Typically, hydrophilic biomolecules cannot penetrate the skin by passive diffusion. Microneedle insertion disrupts skin integrity and compromises its protective function, thus creating pathways (microchannels) fo

SUBMITTER: Nguyen HX 

PROVIDER: S-EPMC9864466 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature