Antiparasitic Activity of Hippeastrum Species and Synergistic Interaction between Montanine and Benznidazole against Trypanosoma cruzi.

ABSTRACT:

Background

Hippeastrum species have a wide range of biological properties. In Argentina, this genus comprises ten widely distributed species.

Purpose

To evaluate the antiparasitic and anticholinesterase activities and chemical profiles of seven Argentinean Hippeastrum species and determine the synergism between the major isolated alkaloid-montanine-and benznidazole in anti-Trypanosoma cruzi activity.

Methods

The antiparasitic activity was evaluated through antiproliferative and viability assays against T. cruzi epimastigotes. Synergism assays were performed using the Chou-Talalay method. AChE and BuChE inhibitory activities were also assessed. The alkaloid composition was obtained using GC-MS analysis.

Results

All extracts showed str

SUBMITTER: Pineiro M 

PROVIDER: S-EPMC9864487 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature