Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons.

ABSTRACT: Altered activity of the ventral pallidum (VP) underlies disrupted motivation in stress and drug exposure. The VP is a very heterogeneous structure composed of many neuron types with distinct physiological properties and projections. Neuronal PAS 1-positive (Npas1⁺) VP neurons are thought to send projections to brain regions critical for motivational behavior. While Npas1⁺ neurons have been characterized in the globus pallidus external, there is limited information on these neurons in the VP. To address this limitation, we evaluated the projection targets of the VP Npas1⁺ neurons and performed RNA-sequencing on ribosome-associated mRNA from VP Npas1⁺ neurons to determine their molecular identity. Finally, we used a chemogenetic approach to manipul

SUBMITTER: Morais-Silva G 

PROVIDER: S-EPMC9864552 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature