In Silico Drug Repurposing in Multiple Sclerosis Using scRNA-Seq Data.

ABSTRACT: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system still lacking a cure. Treatment typically focuses on slowing the progression and managing MS symptoms. Single-cell transcriptomics allows the investigation of the immune system-the key player in MS onset and development-in great detail increasing our understanding of MS mechanisms and stimulating the discovery of the targets for potential therapies. Still, de novo drug development takes decades; however, this can be reduced by drug repositioning. A promising approach is to select potential drugs based on activated or inhibited genes and pathways. In this study, we explored the public single-cell RNA data from an experiment with six patients on single-cell RNA peripheral blood mononuclear cells (PBMC) and cerebro

SUBMITTER: Shevtsov A 

PROVIDER: S-EPMC9864606 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature