Drug Repurposing at the Interface of Melanoma Immunotherapy and Autoimmune Disease.

ABSTRACT: Cancer cells have a remarkable ability to evade recognition and destruction by the immune system. At the same time, cancer has been associated with chronic inflammation, while certain autoimmune diseases predispose to the development of neoplasia. Although cancer immunotherapy has revolutionized antitumor treatment, immune-related toxicities and adverse events detract from the clinical utility of even the most advanced drugs, especially in patients with both, metastatic cancer and pre-existing autoimmune diseases. Here, the combination of multi-omics, data-driven computational approaches with the application of network concepts enables in-depth analyses of the dynamic links between cancer, autoimmune diseases, and drugs. In this review, we focus on molecular and epigenetic metastasis-relat

SUBMITTER: Spitschak A 

PROVIDER: S-EPMC9865219 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature