Conformational Screening of Arbidol Solvates: Investigation via 2D NOESY.

ABSTRACT: Understanding of the nucleation process's fundamental principles in saturated solutions is an urgent task. To do this task, it is necessary to control the formation of polymorphic forms of biologically active compounds. In certain cases, a compound can exist in a single polymorphic form, but have several solvates which can appear in different crystal forms, depending on the medium and conditions of formation, and show different pharmaceutical activity. In the present paper, we report on the analysis of Arbidol conformational preferences in two solvents of different polarities-deuterated chloroform and dimethyl sulfoxide-at 25 °C, using the 2D NOESY method. The Arbidol molecule has various solvate forms depending on the molecular conformation. The method based on the nuclear Overhauser effe

SUBMITTER: Eventova VA 

PROVIDER: S-EPMC9865235 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature