Ontology highlight
ABSTRACT:
SUBMITTER: Csicsak D
PROVIDER: S-EPMC9865396 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Csicsák Dóra D Szolláth Rita R Kádár Szabina S Ambrus Rita R Bartos Csilla C Balogh Emese E Antal István I Köteles István I Tőzsér Petra P Bárdos Vivien V Horváth Péter P Borbás Enikő E Takács-Novák Krisztina K Sinkó Bálint B Völgyi Gergely G
Pharmaceutics 20230113 1
Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability. This work provides a comprehensive investigation of the effect of the particle size, pH, biorelevant media and polymers (PVA and PVPK-25) on the solubility and dissolution of drug formulations using three model compounds with different acid-base ch ...[more]