Ischemic Stroke Induces Skeletal Muscle Damage and Alters Transcriptome Profile in Rats.

ABSTRACT: To establish pathological features of skeletal muscle post-stroke and to provide a background for promising interventions. Adult male SD rats were selected and randomly divided into a control group, a sham group, and a middle cerebral artery occlusion (MCAO) group. The tolerance and capability of exercise were separately collected on days 1, 3, 5, and 7 after the MCAO operation. The neurological deficits, brain infarct volume, soleus histopathology, mRNA-seq analysis, flow cytometry, immunofluorescence, and protein expression analysis were performed on the seventh day. Rats in the MCAO group showed that soleus tissue weight, pulling force, exercise capacity, endurance, and muscle structure were significantly decreased. Moreover, the RNA sequencing array revealed that mitochondrial-mediated

SUBMITTER: Qi H 

PROVIDER: S-EPMC9865444 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature