Inhibitory Effects of 2-Aminoethoxydiphenyl Borate (2-APB) on Three K_V1 Channel Currents.

ABSTRACT: 2-Aminoethoxydiphenyl borate (2-APB), a boron-containing compound, is a multitarget compound with potential as a drug precursor and exerts various effects in systems of the human body. Ion channels are among the reported targets of 2-APB. The effects of 2-APB on voltage-gated potassium channels (K_V) have been reported, but the types of K_V channels that 2-APB inhibits and the inhibitory mechanism remain unknown. In this paper, we discovered that 2-APB acted as an inhibitor of three representative human K_V1 channels. 2-APB significantly blocked A-type Kv channel K_V1.4 in a concentration-dependent manner, with an IC₅₀ of 67.3 μM, while it inhibited the delayed outward rectifier channels K_V1.2 and K_V1.3, with IC₅

SUBMITTER: Zhao W 

PROVIDER: S-EPMC9865587 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature