Excretory/Secretory Proteome of Females and Males of the Hookworm Ancylostoma ceylanicum.

ABSTRACT: The dynamic host-parasite mechanisms underlying hookworm infection establishment and maintenance in mammalian hosts remain poorly understood but are primarily mediated by hookworm's excretory/secretory products (ESPs), which have a wide spectrum of biological functions. We used ultra-high performance mass spectrometry to comprehensively profile and compare female and male ESPs from the zoonotic human hookworm Ancylostoma ceylanicum, which is a natural parasite of dogs, cats, and humans. We improved the genome annotation, decreasing the number of protein-coding genes by 49% while improving completeness from 92 to 96%. Compared to the previous genome annotation, we detected 11% and 10% more spectra in female and male ESPs, respectively, using this improved version, identifying a total

SUBMITTER: Uzoechi SC 

PROVIDER: S-EPMC9865600 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature