Association and Effectiveness of PAX1 Methylation and HPV Viral Load for the Detection of Cervical High-Grade Squamous Intraepithelial Lesion.

ABSTRACT:

Background

PAX1 methylation (PAX1^m) and HPV viral load (VL) have been reported to detect cervical high-grade squamous intraepithelial lesions (HSIL), but the relationship between them is unclear. This study aimed to evaluate the correlation between HPV VL and PAX1^m and its effectiveness in predicting cervical lesions. (2) Methods: A total of 476 women referred to colposcopy for abnormal cervical screening at the Peking University People's Hospital between November 2020 and November 2021 were enrolled. PAX1^m and HPV VL were determined by QMSP and BMRT-HPV reports type-specific VL/10,000 cells, respectively. (3) Results: PAX1^m was significantly increased in HSIL, especially in cervical cancer, but there was no significant difference between

SUBMITTER: Li M 

PROVIDER: S-EPMC9865608 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature