Maternal Iodine Status and Birth Outcomes: A Systematic Literature Review and Meta-Analysis.

ABSTRACT:

Background & aims

Iodine is important for thyroid function during pregnancy to support fetal growth, but studies of maternal iodine status and birth outcomes are conflicting. We aimed to quantify the association between iodine status and birth outcomes, including potential threshold effects using nonlinear dose-response curves.

Methods

We systematically searched Medline and Embase to 10 October 2022 for relevant cohort studies. We conducted random-effects meta-analyses of urinary iodine concentration (UIC), iodine:creatinine ratio (I:Cr), and iodide intake for associations with birth weight, birth weight centile, small for gestational age (SGA), preterm delivery, and other birth outcomes. Study quality was assessed using the Newcastle-Ottawa scale.

Results

Meta-analys

SUBMITTER: Greenwood DC 

PROVIDER: S-EPMC9865661 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature