Cytokines and Hepatocellular Carcinoma: Biomarkers of a Deadly Embrace.

ABSTRACT: Hepatocellular carcinoma (HCC) represents a worldwide health matter with a major care burden, high prevalence, and poor prognosis. Its pathogenesis mainly varies depending on the underlying etiological factors, although it develops from liver cirrhosis in the majority of cases. This review summarizes the role of the most interesting soluble factors as biomarkers for early diagnosis and as recommended targets for treatment in accordance with the new challenges in precision medicine. In the premalignant environment, inflammatory cells release a wide range of cytokines, chemokines, growth factors, prostaglandins, and proangiogenic factors, making the liver environment more suitable for hepatocyte tumor progression that starts from acquired genetic mutations. A complex interaction of pro-infla

SUBMITTER: Pocino K 

PROVIDER: S-EPMC9865677 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature