Low Sodium Intake, Low Protein Intake, and Excess Mortality in an Older Dutch General Population Cohort: Findings in the Prospective Lifelines-MINUTHE Study.

ABSTRACT:

Background

Several studies have found a U-shaped association between sodium intake and mortality. The increased mortality risk of low sodium intake has raised debates and hampers widespread acceptance of public health campaigns and dietary guidelines on reducing sodium intake. Whether the excess risk can be attributed to low sodium intake alone or concomitant inadequate intake of other relevant nutrients is unknown.

Objective

We investigated whether concomitant low protein intake could explain the lower part of the U-shaped association of sodium intake with all-cause mortality.

Methods

We included 1603 individuals aged between 60 and 75 years old from the gender- and socioeconomic status-balanced prospective Lifelines-MINUTHE cohort study. Using multivariable Cox regr

SUBMITTER: Hessels NR 

PROVIDER: S-EPMC9865839 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature