Atherosclerotic-Derived Endothelial Cell Response Conducted by Titanium Oxide Nanotubes.

ABSTRACT: Atherosclerosis lesions are described as the formation of an occlusive wall-vessel plaque that can exacerbate infarctions, strokes, and even death. Furthermore, atherosclerosis damages the endothelium integrity, avoiding proper regeneration after stent implantation. Therefore, we investigate the beneficial effects of TiO₂ nanotubes (NTs) in promoting the initial response of detrimental human atherosclerotic-derived endothelial cells (AThEC). We synthesized and characterized NTs on Ti6Al4V by anodization. We isolated AThEC and tested the adhesion long-lasting proliferation activity, and the modulation of focal adhesions conducted on the materials. Moreover, ultrastructural cell-surface contact at the nanoscale and membrane roughness were evaluated to explain the results. Our find

SUBMITTER: Beltran-Partida E 

PROVIDER: S-EPMC9865858 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature