Design of an Antibiotic-Releasing Polymer: Physicochemical Characterization and Drug Release Patterns.

ABSTRACT: Conventional drug delivery has its share of shortcomings, especially its rapid drug release with a relatively short duration of therapeutic drug concentrations, even in topical applications. Prolonged drug release can be effectively achieved by modifying the carrier in a drug delivery system. Among the several candidates for carriers studied over the years, poly (ether ether ketone), a biocompatible thermoplastic, was chosen as a suitable carrier. Its inherent hydrophobicity was overcome by controlled sulfonation, which introduced polar sulfonate groups onto the polymer backbone. Optimization of the sulfonation process was completed by the variation of the duration, temperature of the sulfonation, and concentration of sulfuric acid. The sulfonation was confirmed by EDS and the degree of su

SUBMITTER: Padinjarathil H 

PROVIDER: S-EPMC9866011 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature