Infection and Persistence of Coxiella burnetii Clinical Isolate in the Placental Environment.

ABSTRACT: Infection by Coxiella burnetii, the etiological agent of Q fever, poses the risk of causing severe obstetrical complications in pregnant women. C. burnetii is known for its placental tropism based on animal models of infection. The Nine Mile strain has been mostly used to study C. burnetii pathogenicity but the contribution of human isolates to C. burnetii pathogenicity is poorly understood. In this study, we compared five C. burnetii isolates from human placentas with C. burnetii strains including Nine Mile (NM) as reference. Comparative genomic analysis revealed that the Cb122 isolate was distinct from other placental isolates and the C. burnetii NM strain with a set of unique genes involved in energy generation and a type 1 secretion syst

SUBMITTER: Zarza SM 

PROVIDER: S-EPMC9866107 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature