Addition of anaerobic coverage for treatment of biliary tract infections: a propensity score-matched cohort study.

ABSTRACT:

Objectives

To evaluate whether additional antibiotics that target anaerobes, including Bacteroides spp., are associated with improved clinical outcomes in patients with biliary tract infections (BTIs).

Methods

This was a retrospective propensity score-matched cohort of adults aged ≥18 years with BTIs, admitted to hospital between 1 April 2015 and 30 March 2021. Eligible patients treated with antibiotics that provided coverage of anaerobes were compared with those treated with comparable regimens without anaerobic coverage. The primary outcome was a composite of mortality within 30 days or relapse within 90 days of source control or completion of antibiotics. Secondary outcomes included length of stay (LOS), duration of antibiotic therapy and adverse drug reactions. OR

SUBMITTER: Simeonova M 

PROVIDER: S-EPMC9866233 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature