Refocus on Immunogenic Characteristics of Convalescent COVID-19 Challenged by Prototype SARS-CoV-2.

ABSTRACT:

Background

Mass basic and booster immunization programs effectively contained the spread of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, also known as COVID-19. However, the emerging Variants of Concern (VOCs) of COVID-19 evade the immune protection of the vaccine and increase the risk of reinfection.

Methods

Serum antibodies of 384 COVID-19 cases recovered from SARS-CoV-2 infection were examined. Correlations between clinical symptoms and antibodies against VOCs were analyzed.

Result

All 384 cases (aged 43, range 1-90) were from 15 cities of Guangdong, China. The specific IgA, IgG, and IgM antibodies could be detected within 4-6 weeks after infection. A broad cross-reaction between SARS-CoV-2 and Severe Acute Respiratory Syndrome Coronaviru

SUBMITTER: Huang X 

PROVIDER: S-EPMC9866260 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature