Therapeutic Strategies to Activate p53.

ABSTRACT: The p53 protein has appropriately been named the "guardian of the genome". In almost all human cancers, the powerful tumor suppressor function of p53 is compromised by a variety of mechanisms, including mutations with either loss of function or gain of function and inhibition by its negative regulators MDM2 and/or MDMX. We review herein the progress made on different therapeutic strategies for targeting p53.

SUBMITTER: Aguilar A 

PROVIDER: S-EPMC9866379 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature