Gut Microbiome Composition and Metabolic Capacity Differ by <i>FUT2</i> Secretor Status in Exclusively Breastfed Infants.

ABSTRACT: A major polymorphism in the fucosyltransferase2 (FUT2) gene influences risk of multiple gut diseases, but its impact on the microbiome of breastfed infants was unknown. In individuals with an active FUT2 enzyme (“secretors”), the intestinal mucosa is abundantly fucosylated, providing mutualist bacteria with a rich endogenous source of fucose. Non-secretors comprise approximately one-fifth of the population, and they lack the ability to create this enzyme. Similarly, maternal secretor status influences the abundance of a breastfeeding mother’s fucosylated milk oligosaccharides. We compared the impact of maternal secretor status, measured by FUT2 genotype, and infant secretor status, measured by FUT2 genotype and phenotype, on early infant fecal microbiome samples collected from 2-month-old

SUBMITTER: Thorman AW 

PROVIDER: S-EPMC9866411 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature