Increased Expression of the Δ133p53β Isoform Enhances Brain Metastasis.

ABSTRACT: The Δ133p53β isoform is increased in many primary tumors and has many tumor-promoting properties that contribute to increased proliferation, migration and inflammation. Here we investigated whether Δ133p53β contributed to some of the most aggressive tumors that had metastasized to the brain. Δ133p53β mRNA expression was measured in lung, breast, melanoma, colorectal metastases and, where available, the matched primary tumor. The presence of Δ133p53β expression was associated with the time for the primary tumor to metastasize and overall survival once the tumor was detected in the brain. Δ133p53β was present in over 50% of lung, breast, melanoma and colorectal metastases to the brain. It was also increased in the brain metastases compared with the matched primary tumor.

SUBMITTER: Jesus ANB 

PROVIDER: S-EPMC9866425 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature