Cancer Vaccines for Triple-Negative Breast Cancer: A Systematic Review.

ABSTRACT: Triple-negative breast cancer (TNBC) is the subtype of breast cancer with the poorest outcomes, and is associated with a high risk of relapse and metastasis. The treatment choices for this malignancy have been confined to conventional chemotherapeutic agents, due to a lack of expression of the canonical molecular targets. Immunotherapy has been recently changing the treatment paradigm for many types of tumors, and the approach of evoking active immune responses in the milieu of breast tumors through cancer vaccines has been introduced as one of the most novel immunotherapeutic approaches. Accordingly, a number of vaccines for the treatment or prevention of recurrence have been developed and are currently being studied in TNBC patients, while none have yet received any approvals. To elucida

SUBMITTER: Hosseini M 

PROVIDER: S-EPMC9866612 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature