S100A6 Protein-Expression and Function in Norm and Pathology.

ABSTRACT: S100A6, also known as calcyclin, is a calcium-binding protein belonging to the S100 protein family. It was first identified and purified more than 30 years ago. Initial structural studies, focused mostly on the mode and affinity of Ca²⁺ binding and resolution of the resultant conformational changes, were soon complemented by research on its expression, localization and identification of binding partners. With time, the use of biophysical methods helped to resolve the structure and versatility of S100A6 complexes with some of its ligands. Meanwhile, it became clear that S100A6 expression was altered in various pathological states and correlated with the stage/progression of many diseases, including cancers, indicative of its important, and possibly causative, role in some of thes

SUBMITTER: Lesniak W 

PROVIDER: S-EPMC9866648 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature