Omics Approaches in Drug Development against Leishmaniasis: Current Scenario and Future Prospects.

ABSTRACT: Leishmaniasis is a zoonotic disease transmitted in humans by the bite of Leishmania-infected phlebotomine sandflies. Each year approximately 58,500 cases of leishmaniasis are diagnosed across the globe, with a mortality rate of nearly seven percent. There are over 20 parasitic strains of Leishmania which are known to cause distinct types of leishmaniasis and pose an endemic threat to humans worldwide. Therefore, it is crucial to develop potential medications and vaccines to combat leishmaniasis. However, the task of developing therapeutic solutions is challenging due to Leishmania's digenetic lifecycle. The challenge is further intensified by cases of resistance against the available drugs. Owing to these challenges, the conventional drug development regimen is further

SUBMITTER: Rabaan AA 

PROVIDER: S-EPMC9866966 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature