Tim-3 Coordinates Macrophage-Trophoblast Crosstalk via Angiogenic Growth Factors to Promote Pregnancy Maintenance.

ABSTRACT: T-cell immunoglobulin mucin-3 (Tim-3) is an important checkpoint that induces maternal-fetal tolerance in pregnancy. Macrophages (Mφs) play essential roles in maintaining maternal-fetal tolerance, remodeling spiral arteries, and regulating trophoblast biological behaviors. In the present study, the formation of the labyrinth zone showed striking defects in pregnant mice treated with Tim-3 neutralizing antibodies. The adoptive transfer of Tim-3⁺Mφs, rather than Tim-3^-Mφs, reversed the murine placental dysplasia resulting from Mφ depletion. With the higher production of angiogenic growth factors (AGFs, including PDGF-AA, TGF-α, and VEGF), Tim-3⁺dMφs were more beneficial in promoting the invasion and tube formation ability of trophoblasts. The blockade of AGFs

SUBMITTER: Cui L 

PROVIDER: S-EPMC9867110 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature