Suppression of RBFox2 by Multiple MiRNAs in Pressure Overload-Induced Heart Failure.

ABSTRACT: Heart failure is the final stage of various cardiovascular diseases and seriously threatens human health. Increasing mediators have been found to be involved in the pathogenesis of heart failure, including the RNA binding protein RBFox2. It participates in multiple aspects of the regulation of cardiac function and plays a critical role in the process of heart failure. However, how RBFox2 itself is regulated remains unclear. Here, we dissected transcriptomic signatures, including mRNAs and miRNAs, in a mouse model of heart failure after TAC surgery. A global analysis showed that an asymmetric alternation in gene expression and a large-scale upregulation of miRNAs occurred in heart failure. An association analysis revealed that the latter not only contributed to the degradation of numerous m

SUBMITTER: Gu M 

PROVIDER: S-EPMC9867119 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature