Fractal Kinetic Implementation in Population Pharmacokinetic Modeling.

ABSTRACT: Compartment modeling is a widely accepted technique in the field of pharmacokinetic analysis. However, conventional compartment modeling is performed under a homogeneity assumption that is not a naturally occurring condition. Since the assumption lacks physiological considerations, the respective modeling approach has been questioned, as novel drugs are increasingly characterized by physiological or physical features. Alternative approaches have focused on fractal kinetics, but evaluations of their application are lacking. Thus, in this study, a simulation was performed to identify desirable fractal-kinetics applications in conventional modeling. Visible changes in the profiles were then investigated. Five cases of finalized population models were collected for implementation. For model di

SUBMITTER: Jung W 

PROVIDER: S-EPMC9867137 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature