Type 1 Diabetes Mellitus: A Review on Advances and Challenges in Creating Insulin Producing Devices.

ABSTRACT: Type 1 diabetes mellitus (T1DM) is the most common autoimmune chronic disease in young patients. It is caused by the destruction of pancreatic endocrine β-cells that produce insulin in specific areas of the pancreas, known as islets of Langerhans. As a result, the body becomes insulin deficient and hyperglycemic. Complications associated with diabetes are life-threatening and the current standard of care for T1DM consists still of insulin injections. Lifesaving, exogenous insulin replacement is a chronic and costly burden of care for diabetic patients. Alternative therapeutic options have been the focus in these fields. Advances in molecular biology technologies and in microfabrication have enabled promising new therapeutic options. For example, islet transplantation has emerged as

SUBMITTER: Rodrigues Oliveira SM 

PROVIDER: S-EPMC9867263 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature