Monitoring the Conformational Changes of the Aβ(25-35) Peptide in SDS Micelles: A Matter of Time.

ABSTRACT: Alzheimer's disease is a neurodegenerative disease characterized by the formation of amyloid plaques constituted prevalently by amyloid peptides. Due to the well-known challenges related to the study in solution of these peptides, several membrane-mimicking systems such as micelle constituted by detergent-i.e., DPC and SDS-have been deeply investigated. Additionally, the strategy of studying short fragments instead of the full-length peptide turned out to be advantageous in exploring the structural properties of the different moieties in Aβ in order to reproduce its pathologic effects. Several studies reveal that among Aβ fragments, Aβ(25-35) is the shortest fragment able to reproduce the aggregation process. To enrich the structural data currently available, in the present work we decided

SUBMITTER: Santoro A 

PROVIDER: S-EPMC9867351 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature