Appraising the Effects of Metabolic Traits on the Risk of Glaucoma: A Mendelian Randomization Study.

ABSTRACT: Metabolic traits are associated with the risk of developing glaucoma in observational studies. To assess whether theses associations reflect causality, we conducted a Mendelian randomization (MR) study. Our study included up to 20,906 glaucoma cases and 438,188 controls. Genetic instruments associated with the concerned 11 exposures at the genome-wide significance level were selected from corresponding genome-wide association studies. Summary-level data for glaucoma were obtained from the UK Biobank, the GERA study, and the FinnGen consortium. Univariable and multivariable MR analyses were conducted separately in two populations. Our results showed that higher genetic liability to type 2 diabetes (T2D) was causally and independently associated with an increased risk of glaucoma (odds ratio

SUBMITTER: Wang K 

PROVIDER: S-EPMC9867384 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature