Leptospira interrogans Serovar Icterohaemorrhagiae Failed to Establish Distinct Infection in Naive Gilts: Lessons Learned from a Preliminary Experimental Challenge.

ABSTRACT: Leptospira is a pathogen involved in fertility problems in pigs. Nevertheless, little information is available on pathogenicity, transmission, tissue tropism, and immune response. The objective of this preliminary study was to induce a diagnostically detectable infection in naïve gilts using Leptospira interrogans serovar Icterohaemorrhagiae to gain the knowledge required for designing a large-scale trial. Eight seronegative fertile gilts were divided into three groups: control (n = 2), challenge (n = 3; 10 mL of 10⁸ leptospires/mL intravenously), and contact (n = 3). A daily clinical examination and periodic sampling of blood, urine, and vaginal swabs were performed until four weeks after infection when necropsy was undertaken. Seroconversion of infected animals w

SUBMITTER: Steinparzer R 

PROVIDER: S-EPMC9867409 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature