Clostridium butyricum Can Promote Bone Development by Regulating Lymphocyte Function in Layer Pullets.

ABSTRACT: Bone health problems are a serious threat to laying hens; microbiome-based therapies, which are harmless and inexpensive, may be an effective solution for bone health problems. Here, we examined the impacts of supplementation with Clostridium butyricum (CB) on bone and immune homeostasis in pullets. The results of in vivo experiments showed that feeding the pullets CB was beneficial to the development of the tibia and upregulated the levels of the bone formation marker alkaline phosphatase and the marker gene runt-related transcription factor 2 (RUNX2). For the immune system, CB treatment significantly upregulated IL-10 expression and significantly increased the proportion of T regulatory (Treg) cells in the spleen and peripheral blood lymphocytes. In the in vit

SUBMITTER: Song M 

PROVIDER: S-EPMC9867449 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature