Gut Microbiota-MicroRNA Interactions in Intestinal Homeostasis and Cancer Development.

ABSTRACT: Pre-clinical models and clinical studies highlight the significant impact of the host-microbiota relationship on cancer development and treatment, supporting the emerging trend for a microbiota-based approach in clinical oncology. Importantly, the presence of polymorphic microbes is considered one of the hallmarks of cancer. The epigenetic regulation of gene expression by microRNAs affects crucial biological processes, including proliferation, differentiation, metabolism, and cell death. Recent evidence has documented the existence of bidirectional gut microbiota-microRNA interactions that play a critical role in intestinal homeostasis. Importantly, alterations in microRNA-modulated gene expression are known to be associated with inflammatory responses and dysbiosis in gastrointestinal dis

SUBMITTER: Nikolaieva N 

PROVIDER: S-EPMC9867529 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature