Myelin water imaging using a short-TR adiabatic inversion-recovery (STAIR) sequence.

ABSTRACT:

Purpose

To develop a new myelin water imaging (MWI) technique using a short-TR adiabatic inversion-recovery (STAIR) sequence on a clinical 3T MR scanner.

Methods

Myelin water (MW) in the brain has both a much shorter T₁ and a much shorter T₂ * than intracellular/extracellular water. A STAIR sequence with a short TR was designed to efficiently suppress long T₁ signals from intracellular/extracellular water, and therefore allow selective imaging of MW, which has a much shorter T₁ . Numerical simulation and phantom studies were performed to investigate the effectiveness of long T₁ signal suppression. TheT₂ * in white matter (WM) was measured with STAIR and compared with T₂ * measured with a conventiona

SUBMITTER: Ma YJ 

PROVIDER: S-EPMC9867567 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature