Global Microbiota-Dependent Histone Acetylation Patterns Are Irreversible and Independent of Short Chain Fatty Acids.

ABSTRACT:

Background and aims

Although germ-free mice are an indispensable tool in studying the gut microbiome and its effects on host physiology, they are phenotypically different than their conventional counterparts. While antibiotic-mediated microbiota depletion in conventional mice leads to physiologic alterations that often mimic the germ-free state, the degree to which the effects of microbial colonization on the host are reversible is unclear. The gut microbiota produce abundant short chain fatty acids (SCFAs), and previous studies have demonstrated a link between microbial-derived SCFAs and global hepatic histone acetylation in germ-free mice.

Approach and results

We demonstrate that global hepatic histone acetylation states measured by mass spectrometry remained largely uncha

SUBMITTER: Saiman Y 

PROVIDER: S-EPMC9867598 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature