Dataset Information

Prevalence of Chlamydia trachomatis infection and evaluation of its genotypes among pregnant women in Tehran, Iran.

ABSTRACT:

Background and objectives

Chlamydia trachomatis is an obligate intracellular pathogen. Infection with C. trachomatis in pregnant women can result in maternal and fetal death, due to pelvic inflammatory disease. Therefore, we aimed to evaluate this infection in pregnant women and identify circulating genotypes of C. trachomatis in Tehran, Iran.

Materials and methods

Endocervical swabs were obtained from 101 pregnant women and tested by PCR assay to detect cryptic plasmid gene. Positive isolates were analyzed for C. trachomatis genotypes through amplification and sequencing of the omp1 gene and alignment with deposited sequences in Gene Bank.

Results

Infection with C. trachomatis was observed in 11 cases, yielding an overall prevalence of 10.8% in total. The majority of infected women were asymptomatic and the rate of infection was found more in women at the age of ≥30 years. However, no statistical association was found between C. trachomatis infection and risk factors in pregnant women. Analysis of isolated sequences revealed genotypes E (44.4%), D and F (both 22.2%), and K (11.2%) as main genotypes of C. trachomatis in this region.

Conclusion

Results of this study showed the prevalence of C. trachomatis infections among pregnant women is relatively high. Identifying the precise rate of infection and associated genotypes in other regions is suggested.

SUBMITTER: Esteghamati A

PROVIDER: S-EPMC9867614 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Prevalence of <i>Chlamydia trachomatis</i> infection and evaluation of its genotypes among pregnant women in Tehran, Iran.

Esteghamati Abdoulreza A Sayyahfar Shirin S Khanaliha Khadijeh K Tavakoli Ahmad A Naghdalipour Mehri M Haghighi Hasanabad Morteza M

Iranian journal of microbiology 20221201 6

<h4>Background and objectives</h4><i>Chlamydia trachomatis</i> is an obligate intracellular pathogen. Infection with <i>C. trachomatis</i> in pregnant women can result in maternal and fetal death, due to pelvic inflammatory disease. Therefore, we aimed to evaluate this infection in pregnant women and identify circulating genotypes of <i>C. trachomatis</i> in Tehran, Iran.<h4>Materials and methods</h4>Endocervical swabs were obtained from 101 pregnant women and tested by PCR assay to detect <i>cr ...[more]

PMID: 36721437

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