Influence of cholestasis on portal vein embolization-induced hypertrophy of the future liver remnant.

ABSTRACT:

Purpose

In the pre-clinical setting, hepatocellular bile salt accumulation impairs liver regeneration following partial hepatectomy. Here, we study the impact of cholestasis on portal vein embolization (PVE)-induced hypertrophy of the future liver remnant (FLR).

Methods

Patients were enrolled with perihilar cholangiocarcinoma (pCCA) or colorectal liver metastases (CRLM) undergoing PVE before a (extended) right hemihepatectomy. Volume of segments II/III was considered FLR and assessed on pre-embolization and post-embolization CT scans. The degree of hypertrophy (DH, percentual increase) and kinetic growth rate (KGR, percentage/week) were used to assess PVE-induced hypertrophy.

Results

A total of 50 patients (31 CRLM, 19 pCCA) were included. After PVE, the DH and KGR we

SUBMITTER: Chang X 

PROVIDER: S-EPMC9867667 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature