Application of metabolomics in urolithiasis: the discovery and usage of succinate.

ABSTRACT: Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone events. It has been shown that the occurrence of calcium oxalate monohydrate (COM) during stone formation is regulated by crystal growth modifiers. Although crystallization inhibitors have been recognized as a therapeutic modality for decades, limited progress has been made in the discovery of effective modifiers to intervene with stone disease. In this study, we have used metabolomics technologies, a powerful approach to identify biomarkers by screening the urine components of the dynamic progression in a bladder stone model. By in-depth mining and analysis of metabolomics data, we have screened five differential metabolites. Through density functional theory studies and bulk crystallization, w

SUBMITTER: Zhang XZ 

PROVIDER: S-EPMC9867757 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature